Differences in gene expression profiles in blood versus lymph nodes and bone marrow from patients with Chronic Lymphocytic Leukemia.

Differences in gene expression profiles in blood versus lymph nodes and bone marrow from patients with Chronic Lymphocytic Leukemia. - Gene expression profiles in blood, lymph nodes and bone marrow in CLL.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31789

Enrollment

Registered

2008-04-17

Start date

2008-02-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Lymphocytic Leukemia white blood cell cancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: B-CLL patients with the minimum age of 18. B-CLL patients who are able to give informed consent. B-CLL patients who undergo lymph node excision or bone marrow biopsy for diagnostic reasons

Exclusion criteria

Exclusion criteria: Patients with other hematological malignancies B-CLL patients younger than 18. B-CLL patients who are unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Differences in gene expression profiles of lymph node and bone marrow versus peripheral blood in patients with chronic lymfocytic leukemia.	—

Secondary

Measure	Time frame
Which regulatory pathways and transcription factors are important in the observed differences in gene expression? Is it possible to develop a new targeted therapy based on the differences in expression of certain genes in lymph nodes and bone marrow versus peripheral blood?	—

Countries

Netherlands

Outcome results