blood born infection lung infection
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Written informed consent from close relative 2. Age > 18 years 3. Patient meets the general criteria for severe sepsis or septic shock, diagnosed less than 24 h prior to study inclusion. 4. and patients meets the general criteria for pneumonia. 5. Systemic arterial catheter in place with continuous pressure monitoring. 6. Patients in whom the clinician is prepared to provide full life support during the duration of the study.
Exclusion criteria
Exclusion criteria: 1. Shock due to any cause other than sepsis (e.g. drug reaction or drug overdose, pulmonary embolus, burn injury etc.) 2. Liver cirrhosis 3. (Insulin-dependent) diabetes mellitus 4. Patients on dialysis (CVVH or other) 5. Pre-existent urea cycle disorders or renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Survival rate in patients with severe septic shock and relationship with AGEs 2. Relationship of AGEs as measured in tissue, blood and as measured using the autofluorescence reader. 3. Relationship between sublingual microcirculation (and reversibility) and multi organ failure in septic patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Relationship between AGEs and capillary permeability in patients with sepsis 2. Relationship between AGEs and oxidative stress. | — |
Countries
Netherlands
Outcome results
None listed