Does a different number, phenotype and/or function of regulatory T cells contribute to the development of asthma?

Does a different number, phenotype and/or function of regulatory T cells contribute to the development of asthma? - The role of regulatory T cells in the development of asthma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31752

Enrollment

175

Registered

2008-03-03

Start date

2008-06-19

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bronchusobstruction recurrent infant wheezing

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: patient is early wheezer patient is 3 years of age

Exclusion criteria

Exclusion criteria: The use of systemic immune modulating medication at the time of blood withdrawal and/or 6 weeks before blood withdrawal. The presence of an active infection at the time of blood withdrawal.

Design outcomes

Primary

Measure	Time frame
Study endpoint: transient or persistent wheezing (= asthma) at age 6 years. Study determinants: number, phenotype and functionality of regulatory T cells in the peripheral blood of early wheezers at age 3 and 5 years. Details on study determinants will be based on the outcome of the pilotstudy (Regulatory T cells in asthma; ABR nummer 19836) preceding the analysis of the samples of this prospective study.	—

Measure

Time frame

Study endpoint: transient or persistent wheezing (= asthma) at age 6 years. Study determinants: number, phenotype and functionality of regulatory T cells in the peripheral blood of early wheezers at age 3 and 5 years. Details on study determinants will be based on the outcome of the pilotstudy (Regulatory T cells in asthma; ABR nummer 19836) preceding the analysis of the samples of this prospective study.

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Secondary

Measure	Time frame
Secondary determinants: Questionnaires: WRC (Weekly Record Card) and questionnaire based upon the ISAAC and PIAMA studies. Lung function: RINTat the age of 3,4,5 and 6 years of age; Volume flow curves before and after β2-mimetics at the age of 6 years. eNose measurement at the age of 3 and 6 years. Peripheral blood: cell numbers and Immunoglobin E levels (total and specific IgE for most common food and inhalent allergens).	—

Measure

Time frame

Secondary determinants: Questionnaires: WRC (Weekly Record Card) and questionnaire based upon the ISAAC and PIAMA studies. Lung function: RINTat the age of 3,4,5 and 6 years of age; Volume flow curves before and after β2-mimetics at the age of 6 years. eNose measurement at the age of 3 and 6 years. Peripheral blood: cell numbers and Immunoglobin E levels (total and specific IgE for most common food and inhalent allergens).

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Countries

Netherlands

Outcome results