high blood pressure hypertension
Conditions
Interventions
Main study:
Hypertensive subjects will be asked to discontinue the intake of
antihypertensive medi-cation three weeks before the start of the study. All
subjects will be asked to start a low salt di
Sponsors
Academisch Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Main study: Inclusion criteria hypertensive subjects: 18-60 years, Caucasian, untreated hypertension>140/90mmHg. Inclusion criteria normotensive subjects : 18-60 years, Caucasian, blood pressure
Exclusion criteria
Exclusion criteria: Obesity (BMI>27kg/m2), cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure), impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA, smoking, alcohol use >4U/day, use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs), and pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Study: - functional recruitment of capillaries in the skin. Amendement: - the angiotensin II AT1-recptor blockade with a single oral dose of 600mg irbesartan. | — |
Secondary
| Measure | Time frame |
|---|---|
| Main Study: - perfused capillary density in the nailfold. - Endothelium- (in)dependent vasodilatation of finger skin microcirculation - Density of arterioloes, capillaries and venules in the bulbar conjunctiva. - Diameter of arterioles and venules in the bulbar conjunctiva. Amendement: - Time-course of angiotensin II AT1-recptor blockade after 600 mg irbesartan - plasma angiotensin II and active plasma renin concentrations (APRC) - Blood pressure drop after intake irbesartan (600mg) and felodipien ER (20mg) | — |
Countries
Netherlands
Outcome results
None listed