common viral infection of the digestive system Enterovirus infection
Conditions
Interventions
None listed
Sponsors
Sint Elisabeth Ziekenhuis
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: A + B are required;A. All Children =38,0°C ) 2. Meningeal inflammation: (anamnestic or with examination at least 2 of the following: headache, photophobia, nuchal rigidity, irritability, lethargy, nausea, vomiting, drowsiness, positive sign of Kernig or Brudzinsky) OR 3. At least 3 of the following: hypothermia, headache, drowsiness, nuchal rigidity, irritability, photofobia, vomiting, diarrhea, anorexia, couhing, myalgia, rash OR 4. Sepsis: Clinical suspicion of an infection plus: - temperature >38,5°C of 2 SD for age OR children 2 SD for age ;B. Signed informed consent by the parent(s)/legal guardian(s)
Exclusion criteria
Exclusion criteria: - Other proven cause of the infection: positive bacterial, viral (other than EV/HPeV), parasitic or fungal/yeast culture or PCR (feces, urine, throat swab, blood, CSF). - Other causes of illness: neoplasma, auto-immune diseases, rheumatic diseases, endocrinologic diseases, gastrooesophageal reflux, etcetera - Known psycho-motor retardation, metabolic diseases with neuro-muscular or cognitive abnormalities - Patients older than 16 years of age - No signed informed consent from the parent(s)/ legal Guardian(s)
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| - Morbidity due to EV/HPeV infection (hospitalization, duration of hospitalization, duration and severity of symptoms, average school- and work absence, duration use of antibiotics) - Antibiotic treatment of patients (antibiotics, stop of antibiotics after diagnosis of EV or HPeV infection) | — |
Primary
| Measure | Time frame |
|---|---|
| - Specific clinical symptoms in patients with proven EV or HPeV infection - Different laboratory diagnostic methods: viral culture, PCR and serology - Several body fluids: feces, urine, throat swab, blood, and eventually CSF - Developmental milestones of children after an EV/HPeV CNS infection | — |
Countries
Netherlands
Outcome results
None listed