The effect of cognitive fatigue on learning in middle aged compared to young adults: a functional MRI study

The effect of cognitive fatigue on learning in middle aged compared to young adults: a functional MRI study - Cognitive fatigue and learning

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31713

Enrollment

Registered

2007-07-05

Start date

2008-03-27

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vermoeidheid fatigue lack of mental energy

Interventions

Participants will be tested after a 2.5 hour cognitive demanding session (experimental condition) and after a 2.5 hour cognitive non demanding session (control condition).

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy young adults between 20 - 25 years, and healthy middle aged adults between 50 - 55 years old.

Exclusion criteria

Exclusion criteria: Significant past or present physical or psychiatric illnesses, the use of medication at the moment of inclusion, and MRI contraindications

Design outcomes

Primary

Measure	Time frame
The main outcome measures are performance (mean reaction time and accuracy) and the blood oxygen level dependent (BOLD) response, a reliable measure for brain activation, during a working memory and verbal memory task.	—

Secondary

Measure	Time frame
Mood and fatigue measured by the 'Profile of Mood States' (POMS) questionnaire. Cortisol levels before and after scanning, measured with a saliva sample	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)