Neutrophil dysfunction and sepsis in ICU patients.

Neutrophil dysfunction and sepsis in ICU patients. - NERTHUS-Study II

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31712

Enrollment

160

Registered

2006-12-12

Start date

2007-03-12

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trauma en acute post-operatieve patiënten multiple organ failure Sepsis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1) Patients admitted to the intensive care unit 2) After sugery or major trauma 3) Age above 18 4) Expected stay > 2 days

Exclusion criteria

Exclusion criteria: Immunological compromised - e.g. patients treated with steroids and/or cytostatic drugs

Design outcomes

Primary

Measure	Time frame
Primary variables: - Degree of inactivity of neutrophils Primary outcome: - Development of inflammatory-induced complications (sepsis/septic shock/(multiple) organ failure) (According to the SIRS/Sepsis criteria)	—

Secondary

Measure	Time frame
Secundary variables: - Normalization of neutrophil receptor profile - Percentage of cells in specific populations of neutrophils. Secundary outcome: - Development of inflammatory-induced complications (sepsis/septic shock/(multiple) organ failure) - Severity of illness during the intensive care period (According to disease severity on admission: APACHE II Score) (According to the maximal SOFA score during admission)	—

Measure

Time frame

Secundary variables: - Normalization of neutrophil receptor profile - Percentage of cells in specific populations of neutrophils. Secundary outcome: - Development of inflammatory-induced complications (sepsis/septic shock/(multiple) organ failure) - Severity of illness during the intensive care period (According to disease severity on admission: APACHE II Score) (According to the maximal SOFA score during admission)

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Countries

Netherlands

Outcome results