Mirrortherapy for improving handfunction in chronic stage after stroke: a study on its effectiveness and an fMRI evaluation of underlying cortical mechanisms.

Mirrortherapy for improving handfunction in chronic stage after stroke: a study on its effectiveness and an fMRI evaluation of underlying cortical mechanisms. - Mirrortherapy in stroke.

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31698

Enrollment

Registered

2007-06-12

Start date

2007-10-10

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

armfunction after stroke hemiplegic upper extremity function

Interventions

It is known from literature that the most effective therapy is the one with a high intensity (hours a day). Since mirror therapy can also be done without supervision of a therapist, it is a potentia

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Main research: Minimal age 18. First ever and only stroke of superior branch of MCA > 1 year ago Non-dominant hand is affected Ability to walk indoors and/or community ambulator Mastery of Dutch language BFM score of 3 or more (voluntary muscle control without domination of pathological synergies);Addendum: Minimal age 18 Mastery of Dutch language

Exclusion criteria

Exclusion criteria: Main research: Other neurological disorders Rheumamatic or orthopaedic disorders to both arms, including shoulder girdle and spinal cord Lacunar stroke syndrome or subarachnoidal haemorrhage prsence of a a functional inconvenient hemiinattention for the affected body side or space of reach hemianopsia Absence of vital or gnostic sensibility;Addendum: Diseases affecting upper-extremity function

Design outcomes

Primary

Measure	Time frame
Measurements will take place prior to (To) and immediately after (T1) and 6 months afer the intervention period (T2). At To personal and clinical data will be collected such as the nature, location and extent of the stroke. In addition, visual-perceptual and visual-constructive disorders, sensibility (stump vs. sharp test), hemineglect/hemianopsia (Star/Line Cancellation [Halligan et al 1994]), apraxia, (Test of apraxia [van Heugten, 1998]) and spasticity (Modified Ashworth Scale (Bohannon, 1987)) will be evaluated. At To, T1 and T2 clinical measurements will take place Function: Brunnström Fügl-Meyer Assessment, Grip strength Skills: Action Research Arm Test, Arm Motor Ability Test, Reaching Actual activity: unsupervised measurement of 48 hours using the Stroke-ULAM (5 accelerometers, 2 electrogoniometers and a data logger). Experienced limitations in daily activities: ABILHAND, Barthel Index Quality of life: EuroQol At To, T1 and T2 a fMRI evaluation will be performed. Addendum: The healthy volunteers will be measured on one occasion with the Stroke-ULAM. The ratio between the amount of use of their dominant arm and the amount of use of their non-dominant arm will be calculated.	—

Measure

Time frame

Measurements will take place prior to (To) and immediately after (T1) and 6 months afer the intervention period (T2). At To personal and clinical data will be collected such as the nature, location and extent of the stroke. In addition, visual-perceptual and visual-constructive disorders, sensibility (stump vs. sharp test), hemineglect/hemianopsia (Star/Line Cancellation [Halligan et al 1994]), apraxia, (Test of apraxia [van Heugten, 1998]) and spasticity (Modified Ashworth Scale (Bohannon, 1987)) will be evaluated. At To, T1 and T2 clinical measurements will take place Function: Brunnström Fügl-Meyer Assessment, Grip strength Skills: Action Research Arm Test, Arm Motor Ability Test, Reaching Actual activity: unsupervised measurement of 48 hours using the Stroke-ULAM (5 accelerometers, 2 electrogoniometers and a data logger). Experienced limitations in daily activities: ABILHAND, Barthel Index Quality of life: EuroQol At To, T1 and T2 a fMRI evaluation will be performed. Addendum: The healthy volunteers will be measured on one occasion with the Stroke-ULAM. The ratio between the amount of use of their dominant arm and the amount of use of their non-dominant arm will be calculated.

—

Secondary

Measure	Time frame
All side effects of the intervention (e.g. increase of shoulder pain) and if possible reasons for drop out will be registered. No secondary study parameters are appilicable for the addendum.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)