The role of inactive follicle stimulating hormone in ovarian dysfunction in galactosemia.

The role of inactive follicle stimulating hormone in ovarian dysfunction in galactosemia. - FSH/Galactosemia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31697

Enrollment

Registered

2006-09-15

Start date

2007-03-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility in galactosemia (inherited metabolic disorder)

Interventions

Study persons are treated with one subcutaneous gift Menopur, 150 resp 225 IU/day during maximum 20 days. This is registered medication regularly used for ovulation induction in infertility treatmen

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: galactosemia ovarian dysfunction

Exclusion criteria

Exclusion criteria: normal ovarian function endocrinological or gynecological tumors

Design outcomes

Primary

Measure	Time frame
1) Estradiol response (yes/no) after recombinant FSH and LH. Estradiol response is defined as (*E2) > 30 pg/ml (Fanchin et al. 1994) 2) FSH glycan structure characterization in galactosemia women	—

Secondary

Measure	Time frame
Baseline FSH (follicle stimulating hormone), LH (luteinizing hormone) AMH (anti- Müllerian hormone) and inhibin are measured at baseline. AMH and inhibin have not been well documented in the galactosemia population. These measurements can be relevant to the understanding of ovarian dysfunction.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)