Genetic and Radiological Screening of First Degree Family Members of Patients with Familial Liver Adenomatosis

Genetic and Radiological Screening of First Degree Family Members of Patients with Familial Liver Adenomatosis - Familial Liver Adenomatosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31682

Enrollment

Registered

2008-05-27

Start date

2008-02-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

benign liver tumor liveradenomatosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with liver adenomatosis by histology or imaging studies 2. First line family members of 1. 2. Minimal age 18 years old 3. Informed consent must be obtained

Exclusion criteria

Exclusion criteria: 1. Patients under 18 years of age 2. Patients who are pregnant 3. Patients who are claustrofobic (MRI) 4. Patients who have magnetic or radiofrequency sensitive implants (MRI) 5. Patients with extreme obesity (MRI+US)

Design outcomes

Primary

Measure	Time frame
- Hepatic lesions on ultrasound and/or contrast-MRI in all patients - Genetic abnormalities (CYP1B1, HNF-1 alpha, ß catenin) in LA index-patients - Genetic abnormalities in first line relatives of LA patients diagnosed with germline mutations. - Genetic abnormalities in first line relatives diagnosed with adenomas on imaging studies	—

Secondary

Measure	Time frame
-Hepatic fat content (MRS) and metabolic profile (blood analysis) in LA patients -Hepatic fat content (MRS) and metabolic profile (blood analysis) in first degree familymembers with germlinemutations and/or adenomas on imaging studies.	—

Countries

Netherlands

Outcome results