ischemic stroke
Conditions
Interventions
Patients are randomized to receive either 300 mg acetylsalicyclicacid iv
(Aspégic) within 1,5 hours after the rt-PA bolus or standard care of rt-PA
without Aspégic.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * patients with an acute ischemic stroke receiving rt-PA thrombolysis * age * 18 years * written informed consent is obtained
Exclusion criteria
Exclusion criteria: * known APT in the previous 5 days(in case of uncertainty the patient may be included) * known thrombocytopenia (thrombocyte count * 100 * 10E9/l) * known contra-indications to ASA treatment (e.g. previous adverse reaction to ASA) * Known anticoagulans usage in the previous 5 days * known legal incompetence of the patient prior to this stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is poor functional health at 3 months defined as dependency or death (mRS 3 * 6). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are symptomatic intracranial or serious systemic haemorrhages within 48 hours, neurological symptoms at 7 * 10 days and survival, disability assessed with the ALDS scale, functional health on the full ordinal range of the modified Rankin Scale at 3 months and the causes of poor outcome. | — |
Countries
Netherlands
Outcome results
None listed