Orbitrap mass spectrometry analysis of exhaled breath condensate (EBC) of asthmatic children - a pilot study

Orbitrap mass spectrometry analysis of exhaled breath condensate (EBC) of asthmatic children - a pilot study - Orbitrap MS analysis of EBC of asthmatic children

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31658

Enrollment

Registered

2007-07-23

Start date

2008-01-28

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma recurrent wheezing

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: Reproducibility study: - Patients between 4 and 18 years - Able to perform EBC collection/ FENO analysis - Atopic patients: RAST class 2 or higher for at least one aeroallergen ever - Healthy controls between 4-18 years with a negative ISAAC questionnaire for asthma, eczema and rhinitis, and normal FENO and flow-volume curve. - Written informed consent;Correlation study: - Patients under the age of 18 - Indication for bronchoscopy for clinical reasons as indicated by the pediatric pulmonologist - Written informed consent

Exclusion criteria

Exclusion criteria: Reproducibility and correlation study: - Extrapulmonary diseases - Mental retardation - Active smoking

Design outcomes

Primary

Measure	Time frame
Reproducibility study: In this study first the reproducibility of EBC profiles will be assessed. Second, we expect to find different patterns in asthmatic and healthy subjects and in atopic versus nonatopic subjects. Correlation study: Correlation between EBC and BALF is the primary study parameter.	—

Secondary

Measure	Time frame
n.v.t.	—

Countries

Netherlands

Outcome results