cognitive deficits memory and concentration problems
Conditions
Interventions
None listed
Sponsors
Antoni van Leeuwenhoek Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: female sufficient proficiency in Dutch language treatment with adjuvant CMF chemotherapy for breast cancer five to twenty years ago over 60 years old
Exclusion criteria
Exclusion criteria: relapse and/or metastases conditions that preclude MRI examination
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Age Educational status Smoking habits Alcohol intake Body mass index Bloodpressure Blood glucose level Activity of hart muscle Condition of coronary arteries Known genetic riskfactors for cognitive decline/dementia Age of menopause Type of menopause (natural or artificial) Use of hormone replacement therapy Depressed mood Self-reported cognitive problems Self-reported medical history and medication use Number of CMF cycles Radiotherapy yes/no Endocrine therapy yes/no | — |
Primary
| Measure | Time frame |
|---|---|
| MRI measures (1.5 Tesla): -2D proton density weighted (PDW) scan: 90 slices/1.6 mm -FLAIR scan: 64 slices/2.5 mm -3D T1W scan:100 slices/1.6 mm -3D T2*W (Susceptibility Weighted SWI) scan:100 slices/1.6 mm -2D Phase Contrast Flow Measurement -Diffusion tensor imaging (25 diffusion tensor directions):39 slices/3.5mm These measures will be used to assess total and regional grey matter, white matter and CSF volume and presence and severity of vascular lesions (white matter lesions, lacunar infarcts, microbleeds). Neuropsychological measures: Mini-Mental State examination the Stroop test the Letter digit substitution task verbal fluency task 15 word verbal learning test These tests will be used to assess impairments in verbal skills, executive functions, attention and memory. | — |
Countries
Netherlands
Outcome results
None listed