disturbed fat and glucose metabolism metabolic syndrome
Conditions
Interventions
Subjects will consume in random order a) a HF diet (40 En% fat, 45 En%
carbohydrates and 15 En% proteins) and b) a LF diet (20 En% fat, 65 En%
carbohydrates and 15 En% proteins).
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age between 18 and 65 years body mass index (BMI) between 18 and 30 kg/m2
Exclusion criteria
Exclusion criteria: - BMI = 30 kg/m2 - Smoking - Serum Total cholesterol > 8.0 mmol/L - Fasting glucose > 7.0 mmol/L - Use of any medication - Active cardiovascular diseases like congestive heart failure or recent ( 3 kg in the past three months) - Impairment of renal function, as evidenced by increased serum creatinine >150 mmol/L - Hepatic diseases as manifested by ALT, AST, GGT, total bilirubin or ALP > 2 times the upper limit of normal - CRP values > 8.0 mg/mL - Abuse of drugs and/or alcohol - Participation in another biomedical study within 1 month prior to the start of this study - Having donated blood (as blood donor) within 1 month prior to start of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Potential early biomarkers of the metabolic syndrome in blood and gene expression profiles in the small intestine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Parameters of the metabolic syndrome in blood, gene expression profiles in PBMC and gut permeability. | — |
Countries
Netherlands
Outcome results
None listed