atherosclerotic plaques hardening of the arteries
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with neurological symptoms due to ischemia in the carotid artery territory and with a carotid stenosis between 30% and 69% as detected by US will be included (n
Exclusion criteria
Exclusion criteria: -Patients with evident other cause of neurological symptoms than carotid stenosis. -Patients that are already scheduled for carotid endarterectomy or stenting -Patients that are already scheduled for an intervention that is associated with embolization. -Severe co-morbidity, amaorosis Fugax, dementia, or pregnancy. -Standard contra-indications for MRI (ferromagnetic implants such as pacemakers and other implanted electrical devices, metallic fragments in the eyes, surgical vessel clips, claustrophobia, documented allergy to contrast media etc).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint is ipsilateral recurrent ischemic stroke alone. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the combined endpoint of ipsilateral ischemic stroke and ipsilateral TIA, and the combined endpoint of ipsilateral ischemic stroke, ipsilateral TIA, and ipsilateral silent infarct as detected on brain MRI. Another secondary endpoint is the influence of patient positioning in the MRI scanner on results of plaque morphology and composition analyses. | — |
Countries
Netherlands
Outcome results
None listed