Comparative study of experimentally observed effects of DBS in STN or GPi in Parkinon*s patients for different stimulation amplitude-frequency combinations.

Comparative study of experimentally observed effects of DBS in STN or GPi in Parkinon*s patients for different stimulation amplitude-frequency combinations. - Relationship of Parkinson symptoms with DBS settings in STN and GPi.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31600

Enrollment

128

Registered

2009-02-25

Start date

2007-11-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Parkinson patients receiving DBS in the STN or GPi - Patients underwent surgery at least three month ago - Patients experiencing good clinical results from DBS - Patients do not experience major fluctuations in symptoms due to medication - Patients are in good physical condition - Patients responding within 5 minutes to changes in the stimulator settings

Exclusion criteria

Exclusion criteria: - Patients who cannot fully cooperate during the experiments - Patients suffering from dementia - Patients suffering from severe dyskinesia

Design outcomes

Primary

Measure	Time frame
During the study the following experiments will be conducted: akinesia: reactiontime bradykinesia: time of movement rigidity: momentum on the elbow and knee joint during passive movement tremor: amplitude and frequency muscle contractions: amplitude, degree of occurence and correlation with stimulationsignal dysarthria: amplitude, fluency and frequency These parameters will be measured in total at sixteen different stimulator settings namely; three amplitude settings for five different frequency settings (15 in total) and one stimulator off condition. This research has been split up into three segments per group to minimize the stress upon one patient. This means that one patient undergoes six different stimulator settings, see protocol pages 10 and 11. Eventually the degree of influence of, and the relationship between, the different settings concerning the surpression of the different Parkinsonian symptoms will be analyzed.	—

Measure

Time frame

During the study the following experiments will be conducted: akinesia: reactiontime bradykinesia: time of movement rigidity: momentum on the elbow and knee joint during passive movement tremor: amplitude and frequency muscle contractions: amplitude, degree of occurence and correlation with stimulationsignal dysarthria: amplitude, fluency and frequency These parameters will be measured in total at sixteen different stimulator settings namely; three amplitude settings for five different frequency settings (15 in total) and one stimulator off condition. This research has been split up into three segments per group to minimize the stress upon one patient. This means that one patient undergoes six different stimulator settings, see protocol pages 10 and 11. Eventually the degree of influence of, and the relationship between, the different settings concerning the surpression of the different Parkinsonian symptoms will be analyzed.

—

Secondary

Measure	Time frame
not applicable.	—

Countries

Netherlands

Outcome results