Functional MRI in cluttering and stuttering

Functional MRI in cluttering and stuttering - fMRI cluttering

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31589

Enrollment

Registered

2008-12-08

Start date

2008-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spraakstoornissen, vloeiendheidsstoornissen babbling

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: to be included as a clutterer: articulatory rate is abnormally fast, irregular or both; in combination with either errors in syllable, word or sentence structure or a ratio disfluencies > 3.0; Stuttering Severity Index 3 % tensed word, syllable or sound repetitions, prolongations or blocks; Stuttering Severity Index > 3.0 A disfluent person can be included as a mix when he experiences stuttering symptoms on top of a high and or irregular speechrate

Exclusion criteria

Exclusion criteria: intelligency quotient

Design outcomes

Primary

Measure	Time frame
Blood-Oxygen-Level Dependent (BOLD) fMRI was used in this study. In this research study brain areas concerned with speech motor and language were examined in a pure clutterer, a pure stutterer and a control. If cluttering is a language based fluency disorder different levels of BOLD will be observed in PWC compared to PWS in area*s of the brain that are known to be involved in language. During speech tasks in complex multisyllabic words PWC will experience different activation levels in areas concerned with speech motor planning (SMA) compared to activation levels in the same areas in PWS. These different levels of activation can be a sign of exposing subtle problems associated with speech motor planning on a higher language level in PWC. If cluttering is a language based fluency disorder that is exposed when automation and or attentional focusing are weak, different levels of BOLD will be observed in PWC in areas involved in automation (for instance cerebellum) and attentional focusing (for instance thalamus) especially in producing more complex low frequency words compared to the brain activity in PWS. When that is the case, it can be hypothesised that cluttering has a different pathogeneses to that of stuttering.	—

Measure

Time frame

Blood-Oxygen-Level Dependent (BOLD) fMRI was used in this study. In this research study brain areas concerned with speech motor and language were examined in a pure clutterer, a pure stutterer and a control. If cluttering is a language based fluency disorder different levels of BOLD will be observed in PWC compared to PWS in area*s of the brain that are known to be involved in language. During speech tasks in complex multisyllabic words PWC will experience different activation levels in areas concerned with speech motor planning (SMA) compared to activation levels in the same areas in PWS. These different levels of activation can be a sign of exposing subtle problems associated with speech motor planning on a higher language level in PWC. If cluttering is a language based fluency disorder that is exposed when automation and or attentional focusing are weak, different levels of BOLD will be observed in PWC in areas involved in automation (for instance cerebellum) and attentional focusing (for instance thalamus) especially in producing more complex low frequency words compared to the brain activity in PWS. When that is the case, it can be hypothesised that cluttering has a different pathogeneses to that of stuttering.

—

Secondary

Measure	Time frame
SData on articulatory rate; articulatory accuracy and smooth-flow; frequency and type of disfluencies will be determined in 1) monologue; 2) reading; 3) oral motor coordination at syllable and word level. Language production skills in written language will be analysed in a written language sample	—

Countries

Netherlands

Outcome results