The effect on embryo-quality of rLH-addition to rFSH for controlled ovarian hyperstimulation in women with poor ovarian reserve

The effect on embryo-quality of rLH-addition to rFSH for controlled ovarian hyperstimulation in women with poor ovarian reserve - L-age study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31586

Enrollment

220

Registered

2008-05-27

Start date

2008-02-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

subfertility

Interventions

Controlled Ovarian Hyperstimulation in a GnRH agonist long luteal protocol with (1) 300 rFSH sc daily alone or (2) 2:1 ratio rFSH : rLH i.e. 300 IU/L rFSH and 150 IU/L rLH sc Followed by a standard IV

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Women are eligible if the following apply: 1. Patients between 35 and 43 years of age 2. Patients with IOF,

Exclusion criteria

Exclusion criteria: A woman must not be entered if any of the following apply: 1. Endocrinopathological disease as: Cushing*s syndrome, adrenal hyperplasia, hyperprolactinaemia, acromegaly, hypothalamic amenorrhea, hypothyroidy, diabetes mellitus type I, PCOS 2. If not willing or able to sign the informed consent form

Design outcomes

Primary

Measure	Time frame
Primary outcome: Percentage of top-quality embryos	—

Secondary

Measure	Time frame
Secondary outcome Number of follicles > 14 mm on hCG day Number of retrieved oocytes Number of metaphase II oocytes Pronuclear morphology Total number of embryos Presence of early cleavage Cleavage stage morphology Number of embryos suitable for transfer Biochemical, clinical, ongoing pregnancies Live-birth rate	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)