Skin resident T cells in atopic dermatitis and psoriasis - Escape from regulation?

Skin resident T cells in atopic dermatitis and psoriasis - Escape from regulation? - Skin resident T cells in atopic dermatitis and psoriasis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31571

Enrollment

Registered

2007-05-22

Start date

2007-05-29

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atopic dermatitis eczema

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - adult (18-70 years of age), male or female patients diagnosed with atopic dermatitis (diagnostic criteria as described by Williams), or (guttate or plaque) psoriasis - biopsy location (about 2x2 cm) should not be treated with topical steroids for at least 1 week

Exclusion criteria

Exclusion criteria: - use of systemic immunosuppressive drugs (i.e., cyclosporin, prednisolone, methotrexate, neotigason, fumaric acid) in the 6 weeks prior to the inclusion - exposure of biopsy location to (extraordinary) UV sunlight (i.e. UV-therapy, sunny holiday) in the 6 weeks prior to inclusion - (secondary) skin infection

Design outcomes

Primary

Measure	Time frame
(a) Differences between the suppressive potential of skin resident regulatory T cells isolated from atopic dermatitis, psoriasis patients and healthy control subjects (b) Differences between the the frequency of regulatory T cells in the skin of patients with atopic dermatitis, psoriasis and healthy control subjects.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results