Myocardial function, oxygen consumption and efficiency assessment in the right ventricle of patients with idiophathic pulmonary hypertrophy using positron emission tomography.

Myocardial function, oxygen consumption and efficiency assessment in the right ventricle of patients with idiophathic pulmonary hypertrophy using positron emission tomography. - Cardiac function and efficiency of the RV in idiopathic PH

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31568

Enrollment

Registered

2008-02-20

Start date

2008-01-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(idiopathic) pulmonary hypertension or chronically increased pressure in the lungvessels resulting in enlarged right ventricle muscle and deterioration

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Newly diagnosed idiopathic PH, NYHA functional classification II to IV, not yet started with PH-medication, age 18 yrs and older

Exclusion criteria

Exclusion criteria: Secundary PH, anemia (Hb

Design outcomes

Primary

Measure	Time frame
- Oxygen consumption measurements of hypertrophic/failing RV with 11C-acetate and 15O-O2 - Cardiac efficiency of RV - Myocardial glucose uptake of RV - Myocardial perfusion reserve of RV (see also Study Objectives no. 1 to 4)	—

Secondary

Measure	Time frame
Relation between the efficiency, glucose uptake and perfusion to the wall stress of the RV (p. 9, wall stress explained) Oxygen consumption and glucose uptake measurements in the intraventricular septum Test-retest of the oxygen gas tracer for measurement of myocardial oxygen consumption	—

Countries

Netherlands

Outcome results