IMPACT: Does the absolute magnitude of Platelet Inhibition inversely correlates with the number of TCD-detected microemboli during and after CAS in asymptomatic patients undergoing carotid artery stenting prior to cardiac surgery who are being pre-treated with either a 300 mg or a 600 mg loading dose of clopidogrel?

IMPACT: Does the absolute magnitude of Platelet Inhibition inversely correlates with the number of TCD-detected microemboli during and after CAS in asymptomatic patients undergoing carotid artery stenting prior to cardiac surgery who are being pre-treated with either a 300 mg or a 600 mg loading dose of clopidogrel? - IMPACT

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31555

Enrollment

Registered

2007-06-26

Start date

2007-01-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carodit stenosis

Interventions

All patients will receive a loading dose of 600mg of study medication. The first group will receive 300 mg of clopidogrel and 300 mg placebo, the second group will receive 600mg of clopidogrel

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -patient > 18 years of age -patient accepted for CABG and CAS -temporal window for TCD available

Exclusion criteria

Exclusion criteria: -severe renal impairment, abnormal liver function, malignancy, febrile disorder, acute or chronic inflammatory disease and other diseases influencing platelet reactivity -extreme tortuositas or calcification of the lesion -patients with active bleeding or at high-risk of bleeding -uncontrolled hypertension ( > 180/110 mmHg)despite optimal medication

Design outcomes

Primary

Measure	Time frame
The number of TCD-detected microemboli during a 60 minutes monitoring period immediately after the CAS procedure. The absolute level of platelet inhibition after pre-treatment	—

Secondary

Measure	Time frame
The cerebral complications in the first 30 days following the procedure.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)