B-cell differentiation defects and clinical complications in antibody deficiency syndromes with a focus on Common Variable Immunodeficiency

B-cell differentiation defects and clinical complications in antibody deficiency syndromes with a focus on Common Variable Immunodeficiency - B-cell differentiation defects in antibody deficiency syndromes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31550

Enrollment

130

Registered

2007-06-04

Start date

2007-08-20

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorder of antibody production humoral immunodeficiency

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with antibody deficiency syndromes and patients with clinical complications that can be the result of antibody deficency syndromes like bronchiectasis of unknown origin or repeated severe ENT infections without known cause despite extensive examinations.

Exclusion criteria

Exclusion criteria: Cystic fibrosis, anatomical abnormalities of the respiratory tract, primairy ciliary dyskinesia. Age below 2 years of age.

Design outcomes

Primary

Measure	Time frame
Primairy parameters: B-cell differentiation and maturation defects. Immunological outcome: in vivo vaccination response (adults). History of response to vaccination (children). Clinical outcome: The presence of auto-immune disease and the appearance or progression (if already present at the moment of diagnosis) of permanent pulmonary damage.	—

Secondary

Measure	Time frame
Frequency of pneumonia after diagnosis Number of pneumonias with hospital admission before diagnosis Bronchiectasis before diagnosis Presence or appearance of malignacies Quality of life Nasopharyngeal carriage of bacteria Carriage of abdominal parasites	—

Countries

Netherlands

Outcome results