kidney disease renal failure
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - > 18 years -Patients have to belong to one of the following categories: those with Fabry disease, those with HIV, those with a status after renal transplantation or those that are willing to donate a kidney. -Patients (from the outpatient clinic of metabolic diseases and infectious diseases) in whom renal function was measured with 125I-labeled iothalamate/131I-labeled hippuran GFR in the previous year (i.e patients with Fabry disease or with HIV). -Stable renal function as estimated by a stable serum creatinine during the previous year.
Exclusion criteria
Exclusion criteria: -Female patients who are pregnant or unwilling to use adequate contraception during the study. -A known allergy to either 51Cr-EDTA or gadolineum DTPA (Magnevist).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The accuracies of GFR determination using 51Cr-EDTA, Gd-DTPA, cystatin C (using the Hoek-formula) and creatinine (using the MDRD - and Cockcroft and Gault formula) will be compared to continuous 125I-labelled iothalamate/ 131I-labelled hippuran infusion as gold standard. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Gd-DTPA, cystatin C (using the Hoek-formula) and creatinine (using the MDRD - and Cockcroft and Gault formula) will be compared to 51Cr-EDTA. 2. Subanalysis of these parameters in the four different patients groups. | — |
Countries
Netherlands
Outcome results
None listed