fatty degeneration obesity
Conditions
Interventions
2 mornings consumption of low- or high-GI cookie
2 mornings consumption of glucose solution
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Lean (BMI 20-25kg/m²) as well as obese (BMI 30-35 kg/m²) non-smoking men, aged 18-65. Because smoking might influence inflammatory parameters we will use non-smokers.
Exclusion criteria
Exclusion criteria: - unstable body weight (weight gain or loss >3 kg in the past 3 months) - Quetelet-index (BMI) 25 kg/m2 or 35 kg/m2 - diabetes mellitus and anti-diabetic medication (e.g. PPARγ agonists) - severe medical conditions that might interfere with the study such as hypertension, epilepsy, astma, COPD, inflammatory bowel diseases and rheumatoid arthritis, autoimmune disorders, allergies - use of medication or a diet known to affect serum lipid levels - history of coronary heart disease - abuse of drugs and/or alcohol - smoking - women - use of an investigational product within the previous 30 days - not willing to give up being a blood donor from 4 weeks before the start of the study and during the study. - impossible of difficult to venipuncture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6 | — |
Secondary
| Measure | Time frame |
|---|---|
| Is there a difference between lean and obese subjects in metabolic risk markers after consuming a low- or high-GI food product? | — |
Countries
Netherlands
Outcome results
None listed