-Study on the effect of the interaction of short-term combined use of NSAIDS with diuretics and/or RAAS-inhibitor in post-operative elective orthopedic patients

-Study on the effect of the interaction of short-term combined use of NSAIDS with diuretics and/or RAAS-inhibitor in post-operative elective orthopedic patients - KNION-study

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31513

Enrollment

124

Registered

2008-05-19

Start date

2008-06-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure hypertension

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: elective knee- or hipreplacement use of RAAS-inhibitors and diuretics

Exclusion criteria

Exclusion criteria: hipfracture with replacement revision of the knee or hip hospitalisation

Design outcomes

Primary

Measure	Time frame
- systolic bloodpressure - diastolic bloodpressure - glomulair filtration rate	—

Secondary

Measure	Time frame
- oedema - serum creatinine - serum Na+ - serum K+ - consult cardiology/internal - dose reduction/escalation diuretics/RAAS-inhibitor	—

Countries

Netherlands

Outcome results