Carbamoyl-phosphate synthetase gene polymorphisms influencing plasma L-arginine concentrations in preterm infants

Carbamoyl-phosphate synthetase gene polymorphisms influencing plasma L-arginine concentrations in preterm infants - CPS-polymorphisms and NEC

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31504

Enrollment

100

Registered

2007-06-28

Start date

2007-07-09

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

enteritis in preterm infants

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: VLBW infants (

Exclusion criteria

Exclusion criteria: Blood transfusion, enteral or parenteral protein intake, or inhaled nitric oxide administration before time of the bloodsample (obtained between 6 and12 hours after birth). Parents not able to give informed consent.

Design outcomes

Primary

Measure	Time frame
The association between the T1405N SNP in the CPS-1 gene and lower plasma L-arginine concentrations	—

Secondary

Measure	Time frame
The difference in genotype distribution of this polymorphism between VLBW infants developing necrotizing enterocolitis and those who do not.	—

Countries

Netherlands

Outcome results