Does borderzone contrast enhancement on intraoperative MRI during high grade glioma resection correlate with residual tumor?

Does borderzone contrast enhancement on intraoperative MRI during high grade glioma resection correlate with residual tumor? - Borderzone sampling

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31501

Enrollment

Registered

2007-09-14

Start date

2008-10-29

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

high grade glioma malignant brain tumor

Interventions

Intraoperative MRI guided resection of a brain tumor with navigation guided biopsies from the borders of the resection cavity after acquiring intraoperative MRI images.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - supratentorial brain tumor, on contrast enhanced MRI suspect for a high grade glioma - indication for resection of the tumor - age >= 18 years - WHO Performance Scale

Exclusion criteria

Exclusion criteria: - recurrent tumor - multiple tumor localizations - prior radiotherapy on the skull - prior chemotherapy

Design outcomes

Primary

Measure	Time frame
The relation between the shape and size of contrast enhancement on intraoperative MRI at the resection cavity border, and the presence of residual tumor tissue.	—

Secondary

Measure	Time frame
* The relation between possible contrast enhancement and contrast enhancing tissue volume on the last intraoperative MRI scan and the early diagnostic MRI scan (within 72 hours after surgery). * Postoperative clinical condition (WHO Performance Scale). * Survival (Kaplan Meier)	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)