psychiatrische aandoeningen mood disorder psychosis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects have to satisfy the following criteria in order to participate in the study: - Give written informed consent - Aged between 18-65 years of age;Specific for schizophrenia patients: - Do have a DSM-IV diagnosis of Schizophrenia - Do not chronically use medication, other than psychiatric medication - Are not in an acute psychotic episode, but stable for at least 6 months;Specific for MDD patients: - Do have a DSM-IV diagnosis of Major Depressive Disorder - Do not chronically use medication, other than psychiatric medication - Are not in an acute depressive episode, but stable for at least 6 months - Have had at least two depressive episodes and at least one hospital admission due to affective symptoms
Exclusion criteria
Exclusion criteria: - Ferrous objects in or around the body (e.g. braces, pacemaker, metal fragments) - Claustrophobia - Drug or alcohol abuse over a period of six months prior to the experiment - History of closed-head injury - History of neurological illness or endocrinological dysfunction - A pacemaker;Specific for the healthy individuals: - A psychiatric history - Chronic use of medication - A first-degree family member with a psychiatric illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the relationship between susceptibility to stress (cortisol response after a psychosocial stressor) and structural and functional brain measurements, and how this association is medicated by genotype (COMT, 5HTTLPR). | — |
Countries
Netherlands
Outcome results
None listed