schizophrenia
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age between 18 and 50;specific for schizophrenia patients: DSM-IV diagnosis of schizophrenia
Exclusion criteria
Exclusion criteria: - Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments) - Drug or alcohol abuse over a period of six months prior to the experiment - History of closed- or open-head injury - History of neurological illness or endocrinological dysfunction - Claustrophobia - Major medical history - Chronic use of medication - History of epilepsy - History of epilepsy in first-degree relatives - Incapability of giving an informed consent - Symptoms indicative of schizophrenia (healthy controls only) - Symptoms indicative of schizophrenia in first-degree relatives (healthy controls only) - pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Differences in brain activity as measured with functional MRI between siblings with various allele-variants per candidate- gene - Differences in brain activity as measured with fMRI between siblings with psychotic or schizotypic symptoms compared to siblings without such symptoms - Differences in genetic profile of: o Siblings with psychotic or schizotypic symptoms o Siblings without psychotic or schizotypic symptoms o A matched population of healthy controls | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain activity as measured with functional MRI, expressed in percent signal change. Control variables: - behavioural measures, expressed in reaction times (ms) and accuracy - heart rate, expressed in beats per minute (bpm), heart rate variability - respiration, expressed in respiration volume per time | — |
Countries
Netherlands
Outcome results
None listed