chronic bronchitis and emphysema. COPD
Conditions
Interventions
None listed
Sponsors
Isala Klinieken
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Patients > 40 years old, in our outpatient clinic with chronic cough and COPD (gold 2-4). 2. Chronic cough is defined as a cough > 12 weeks duration, 2 years in a row. 3. Analysed for bronchiectasis prior to participation.
Exclusion criteria
Exclusion criteria: 1. Use of i.v. or oral corticosteroids and or antibiotics for an exacerbation 3 weeks before inclusion 2. Patients suffering from other relevant lung diseases. 3. Clinically relevant abnormal laboratory values suggesting an unknown disease requiring further clinical evaluation. 4. Liver disease, (ALAT and/or ASAT levels two or more times the upper limit of normal). 5. Pregnancy or lactation. 6. Use of macrolides the last 6 weeks prior to inclusion. 7. Allergy or intolerance to macrolides. 8. Other research medication started 2 months prior to inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LCQ (leicester cough questionnaire) | — |
Secondary
| Measure | Time frame |
|---|---|
| Short form 36, SGRQ. FEV1, VC (spirometry), inflammatory markers sputum, microbiology sputum. | — |
Countries
Netherlands
Outcome results
None listed