A pilot study of immunorespons in children with Down syndrome after Respiratory Syncytial Virus (RSV) lower respiratory tract infections (LRTI)

A pilot study of immunorespons in children with Down syndrome after Respiratory Syncytial Virus (RSV) lower respiratory tract infections (LRTI) - RSV and Down

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31485

Enrollment

100

Registered

2007-01-02

Start date

2007-05-03

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Down syndrome Mongols

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Down syndrome, age 0-12 years; healthy matched-controls

Exclusion criteria

Exclusion criteria: Bronchopulmonary dysplasia, prematurity (gestational age

Design outcomes

Primary

Measure	Time frame
The primary outcome is the difference in immunorespons after RSV LRTI in children with DS and 'healthy' peers. The difference will be stated upon: RSV specific cytokine production; total number of T-cells, B-cells, Antigen Presenting Cells, Natural Killer cells and Dendritic cells; general cytokine expression.	—

Secondary

Measure	Time frame
Age, sex and ethnic background will be taken into account as variables in the analyses.	—

Countries

Netherlands

Outcome results