Role for hypoxia, hypoxia inducible factor HIF1a and vessel formation in early Rheumatoid Arthritis (RA)

Role for hypoxia, hypoxia inducible factor HIF1a and vessel formation in early Rheumatoid Arthritis (RA) - Role for hypoxia, hypoxia inducible factor and vessels in early RA

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31469

Enrollment

Registered

2008-01-29

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients will have to fulfil the ACR classification criteria for Rheumatoid Arthritis (RA) The duration of disease should be less than 1 year. Patients need to have an actively inflamed knee or ankle joint. There is an indication for treatment with MTX (methotrexate) No contraindications against MTX treatment

Exclusion criteria

Exclusion criteria: No RA Contraindications against MTX

Design outcomes

Primary

Measure	Time frame
1. To investigate the amount of HIF1a expression and (neo-) angiogenesis in early RA. secondary	—

Secondary

Measure	Time frame
1. To explain the difference in HIF1a expression and (neo-) angiogenesis between MTX responders and non-responders according to DAS response criteria. 2.To study whether there is a relation between hypoxia, subsequent HIF1a expression and (neo-) angiogenesis and the amount of inflammatory cells.	—

Countries

Netherlands

Outcome results