n.v.t. gaat om onderzoek bij gezonde vrijwilligers n.v.t.
Conditions
Interventions
Subjects receive single oral doses of dexchlorpheniramine 4 mg, lorazepam 1 mg
(as active control) and placebo. Balancing of treatments will be accomplished
by randomly assigning subjects to one of
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Males and females Age 18-45 Good phsyical health as determioned by a medical history questionnaire, medical screening by a physician, ECG and blood haematology Absence of any medical, endocrine and neurological condition Body mass index (weight/length2) between 18 and 28 kg/m2 Blood pressure between 100-150 Hg systolic and 60-90 diastolic. Written informed consent
Exclusion criteria
Exclusion criteria: History of or current drug abuse Current use of psychoactive medicinal treatment Drinking more than 20 alcoholic consumptions per week For females: pragnancy or lactation Drinking more than 5 cups of caffeinated drinks per day Smoking more than 5 cigarettes per day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are indicators of perceptual-motor performance and brain activity as measured with a subcritical tracking task and choice reaction time task in the MRI scanner (fMRI). Dependent variables are tracking error, reaction time and BOLD response | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective alertness | — |
Countries
Netherlands
Outcome results
None listed