The molecular mechanism of cholestatic pruritus

The molecular mechanism of cholestatic pruritus - Pruritus

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31450

Enrollment

Registered

2008-04-17

Start date

2007-06-22

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICP (Intrahepatic cholestasis of pregnancy) PBC (primary biliary cirrhosis) PSC (primary sclerosing cholangitis)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Male or female patient with cholestatic liver disease, adult, able to give fully informed written consent; gamma-glutaryl-transpeptidase > 1.5 above normal, alkaline phosphatase > 1.5 above normal, bilirubin normal or above normal

Exclusion criteria

Exclusion criteria: Other causes of itch than cholestatic liver disease

Design outcomes

Primary

Measure	Time frame
Parameters measured in serum: bile acids, bile acid metabolites, progesterone metabolites, estrogen metabolites, possible (in)direct pruritogens, standard serum liver tests	—

Countries

Netherlands

Outcome results