Response of sigmoïd epithelium to secretory stimuli in adults with constipation

Response of sigmoïd epithelium to secretory stimuli in adults with constipation - Response of sigmoid epithelium to secretagogues

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31445

Enrollment

Registered

2009-01-13

Start date

2007-10-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

constipation obstipation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients with constipation defined by the Rome II criteria. At least 12 weeks of 2 or more of: 1. straining 1/4 defecations 2. Lumpy/ hard stools in 1/4 defecations 3. sensations of incomplete evacuation in 1/4 defecations; 4. sensation of anorectal obstruction/ blockade in 1/4 defecations; 5. manual maneuvres to facilitate >1/4 defecations 6.

Exclusion criteria

Exclusion criteria: - Administration of oral laxatives 2 days prior to the sigmoidoscopy; - Administration of oral drugs affecting the motility of the intestine 2 days prior to the sigmoidoscopy; - Malignancy of the gasto-intestinal tract and any other tract; - Patients with metabolic disease (hypothyreoidia), inflammatory bowel disease, gastrintestinal surgery or congenital disorders; - Patients with diarrhoea.

Design outcomes

Primary

Measure	Time frame
Primary: -Response of sigmoid tissue to secretagogues	—

Secondary

Measure	Time frame
Secondary: - Baseline current - Baseline potential difference - CLC2 and CFTR expression in the mucosa of the sigmoid	—

Countries

Netherlands

Outcome results