high grade glioma
Conditions
Interventions
None listed
Sponsors
MAASTRO clinic
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: •Histologically confirmed gliomas III - IV (glioblastoma, anaplastic astrocytoma, gliosarcoma) at primary diagnosis •WhO PFS 18 years •Availability of deep fresh frozen tissue for molecular biologic evaluation - if possible •Patient able to tolerate full course of conventional RT and follow serial scanning •No previous radiotherapy to the head and neck and brain area. •Prior neurosurgery within 6 weeks of treatment •No previous chemotherapy before treatment of the glioma. Standard radiochemotherapy with temozolomide is not excluded •No prior or concurrent medical condition which would make treatment difficult to complete. Medication with steroids is allowed. •No incapacitated patients.
Exclusion criteria
Exclusion criteria: No Histologically confirmed gliomas II - IV (glioblastoma, anaplastic astrocytoma, gliosarcoma) at primary diagnosis; WHO PFS >2 Tumours which do not enhance on pre-operative imaging. Post-operative not enough visible resiudal tumor on PET or status after biopsy only Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The end-point is the prediction of the localisation of the persistent tumour cells with remaining FDG-uptake -at the end of radiotherapy compared to the baseline PET and PET during radiotherapy,- as a function of the FDG-uptake dynamics during radiotherapy. | — |
Countries
Netherlands
Outcome results
None listed