Infections in Stable Asthmatic Patients: Non Invasive Detection

Infections in Stable Asthmatic Patients: Non Invasive Detection - Infections in Stable Asthmatic Patients: Non Invasive Detection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31432

Enrollment

Registered

2008-08-18

Start date

2008-07-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Men and/or women age between 18-65 years - History of episodic chest tightness and wheezing (for the MILD and SEVERE astmatic patients) - Prebronchodilator FEV 1 *80% predicted (for the MILD asthmatic patients) - Reversibility in FEV1>12% predicted, or documented hyperesponsiveness (PC20 methacoline 8mg/ml) (for the HEALTHY subjects) - Negative history of pulmonary and any other relevant diseases. (for the HEALTHY subjects)

Exclusion criteria

Exclusion criteria: - History of current alcohol or drug abuse, as judged by the investigator. - Subjects who have had an exacerbation or a chest infection within the last 4 weeks prior to the study. - Uncontrolled hypertension-systolic blood pressure(BP)>200 mmHg and/or diastolic BP>100 mmHg. - Concomitant disease or condition which could interfere with the conduct of the study or which would, in the opinion of the investigator, pose an unacceptable risk to the patient in this study

Design outcomes

Primary

Measure	Time frame
The first aim of the study is to determine the prevalence of latent infections by non invasive assessment of induced sputum, exhaled breath condensate and nasal/throat swabs in stable asthmatic patients and controls.	—

Secondary

Measure	Time frame
The severity of airway inflammation based on sputum cell differentials	—

Countries

Netherlands

Outcome results