Individuals at high-risk for developing pancreatic cancer: surveillance by endosonography and magnetic resonance imaging: FAMILIAL PANCREATIC CANCER SURVEILLANCE STUDY

Individuals at high-risk for developing pancreatic cancer: surveillance by endosonography and magnetic resonance imaging: FAMILIAL PANCREATIC CANCER SURVEILLANCE STUDY - FAMILIAL PANCREATIC CANCER SURVEILLANCE STUDY

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31426

Enrollment

150

Registered

2007-07-16

Start date

2007-03-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pancreatic cancer pancreatic neoplasia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: PC prone hereditary syndromes with a cumulative lifetime risk >10% on PC, or PC prone hereditary syndromes with a unknown cumulative lifetime risk, or

Exclusion criteria

Exclusion criteria: Clinical evidence of PC and / or PC in the medical history, Medical comorbidities or coagulopathy that contraindicate endoscopy, Medical comorbidities or coagulopathy that contraindicate pancreatic surgery, Karnofsky performance score

Design outcomes

Primary

Measure	Time frame
Frequency of pancreatic cancer or precursor lesions.	—

Secondary

Measure	Time frame
The false positive rate of surveillance strategy in FPC after resection surgery Interobserver variability of endosonography in the surveillance of FPC Interobserver variability of MRI in the surveillance of FPC Cost-effectiveness of different surveillance scenarios in this population of cancer-prone individuals Identification of novel biomarkers which accurately detect early pancreatic neoplasia. Identification of unknown gene(s) responsible for the hereditary forms of PC Determination of pancreatic neoplasia prevalence in known hereditary syndromes in order to improve risk stratification and provide more accurate estimates of individual cancer risk.	—

Measure

Time frame

The false positive rate of surveillance strategy in FPC after resection surgery Interobserver variability of endosonography in the surveillance of FPC Interobserver variability of MRI in the surveillance of FPC Cost-effectiveness of different surveillance scenarios in this population of cancer-prone individuals Identification of novel biomarkers which accurately detect early pancreatic neoplasia. Identification of unknown gene(s) responsible for the hereditary forms of PC Determination of pancreatic neoplasia prevalence in known hereditary syndromes in order to improve risk stratification and provide more accurate estimates of individual cancer risk.

—

Countries

Netherlands

Outcome results