Hypercoagulable Atrial Appendages in atrial fibrillation (AF): a cross sectional pilot study

Hypercoagulable Atrial Appendages in atrial fibrillation (AF): a cross sectional pilot study - Hypercoagulable Atrial Appendages in AF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31424

Enrollment

Registered

2008-01-24

Start date

2008-02-26

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria cases 1. Electrocardiographically established diagnosis of atrial fibrillation 2. Need for thoracic surgery (requiring median sternotomy);Inclusion criteria controls 1. 18 years or older 2. Need for thoracic surgery (requiring median sternotomy)

Exclusion criteria

Exclusion criteria: Exclusion criteria cases 1. No written informed consent 2. Age under 18 years 3. Severe mitral or aortic valve disease 4. Secondary AF 5. Kidney dysfunction (GFR

Design outcomes

Primary

Measure	Time frame
Degree of TM an TF expression and activity in the atrial appendages Degree of CML-CEL expression in the atrial appendages	—

Secondary

Measure	Time frame
Serum CML-CEL values Skin auto fluorescence values of AGEs Viral presence in atrial appendages Atrial appendage proteomics AF score (representing the electrophysiological tissue properties)	—

Countries

Netherlands

Outcome results