Age dependency of midazolam requirements in a pediatric intensive care unit: a prospective clinical study

Age dependency of midazolam requirements in a pediatric intensive care unit: a prospective clinical study - midazolam requirements in a pediatric intensive care unit

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31394

Enrollment

Registered

2007-07-23

Start date

2007-04-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

betreft kinderen opgenomen op een kinder intensive care afdeling met een diversiteit aan aandoeningen sleep medication

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: All children, age between 0-12 years, being admitted between July 2007 and July 2008 to the pediatric intensive care unit and to be expected being mechanically ventilated for 48 h and permesiion obtained within 24 h after admission.

Exclusion criteria

Exclusion criteria: If midazolam is not the first line drug for sedation. Use of midazolam as anti-epileptic medication. No arteila line or central venous line present. Known liver or renal function disorders or head trauma or psychomotoric retardation.

Design outcomes

Primary

Measure	Time frame
- Mean daily dosage of midazolam per day will be comapred between different ages (Kruskall Wallis test). - Analysis of pharmacokinetics (plasma concentrations) and pharmacodynamics (Comfort-B score) with the NON-linear Mixed Effect Modelling (NONMEM).	—

Secondary

Measure	Time frame
not applicable.	—

Countries

Netherlands

Outcome results