psychose - delusions
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects have to satisfy the following criteria in order to participate in the study: - Do not have a pacemaker - Do not have metal materials in the head (except for dental braces) - Give written informed consent - Do not have a major medical history;Specific for patients: - Do have a DSM-IV diagnosis of Schizophrenia, Schizoaffective disorder or Bipolar disorder, or expereince a first psychotic episode - Do not chronically use medication, other than psychiatric medication - Unable to give consent;Specific to healthy subjects: - Do not have a psychiatric history - Do not have a first-degree family member with a psychiatric illness - Do not chronically use medication
Exclusion criteria
Exclusion criteria: - Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments) - Drug or alcohol abuse over a period of six months prior to the experiment - History of closed-head injury - History of neurological illness or endocrinological dysfunction - Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| What are the age-related trajectories of brain change in patients with schizophrenia, schizoaffective disorder, or bipolar disorder, relative to healthy individuals? | — |
Secondary
| Measure | Time frame |
|---|---|
| Are the age-related brain changes seen in patients clinically relevant, i.e. the association with medication intake, outcome and symptoms will be tested. Can the age-related brain changes be explained by genetic or environmental factors? | — |
Countries
Netherlands
Outcome results
None listed