Sleep in Dutch Veterans with Deployment Related Post Traumatic Stress Disorder; Analyses of Polysomnography and HPA-axis Parameters

Sleep in Dutch Veterans with Deployment Related Post Traumatic Stress Disorder; Analyses of Polysomnography and HPA-axis Parameters - Sleep in Deployment Related Post Traumatic Stress Disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31378

Enrollment

Registered

2007-11-13

Start date

2007-11-14

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psychological trauma PTSD

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Age between 18 - 55 - Male - Veterans or active military personnel - History of deployment (PTSD and trauma controls) - CAPS > 50 (PTSD patients)

Exclusion criteria

Exclusion criteria: - Substance or alcohol dependence within the past six months - History of psychiatric disorders (trauma controls, healthy controls) - CAPS > 18 (trauma controls) - Significant psychological trauma in the past (healthy controls) - Any clinically significant abnormal finding during medical history or physical examination - Anemia (hemoglobin

Design outcomes

Primary

Measure	Time frame
The primary outcome measures are the number of arousals and nocturnal exctrion of cortisol.	—

Secondary

Measure	Time frame
Secondary objectives are 1. Other PSG parameters 2. Nocturnal excretion of catecholamines and hormones of the HPA axis (other than cortisol) 3. Correlations of plasma concentration of catecholamines and hormones of the HPA axis with number of arousals and other PSG parameters 4. Correlation of subjective sleep complaints with number of awakenings and other PSG parameters 5. Correlation of objective and subjective sleep quality with temperament, general psychological and somatic well being, according to VTCI, SCL-90 and CIS 6. Correlation of performance on memory task (delayed recall) and number of arousals	—

Measure

Time frame

Secondary objectives are 1. Other PSG parameters 2. Nocturnal excretion of catecholamines and hormones of the HPA axis (other than cortisol) 3. Correlations of plasma concentration of catecholamines and hormones of the HPA axis with number of arousals and other PSG parameters 4. Correlation of subjective sleep complaints with number of awakenings and other PSG parameters 5. Correlation of objective and subjective sleep quality with temperament, general psychological and somatic well being, according to VTCI, SCL-90 and CIS 6. Correlation of performance on memory task (delayed recall) and number of arousals

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Countries

Netherlands

Outcome results