Prevention of psychosis with a cognitive behavioural intervention in help-seeking young people with an at risk mental state for developing psychosis

Prevention of psychosis with a cognitive behavioural intervention in help-seeking young people with an at risk mental state for developing psychosis - EDIE-NL Early Detection Intervention Evaluation - Netherlands

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31359

Enrollment

240

Registered

2007-08-21

Start date

2007-12-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mensen met een therapievraag bij de ambulante ggz met een hoogrisico op het ontwikkelen van een psychose at risk mental state psychosis

Interventions

Intervention: The effective intervention is the Dutch translation of the protocol as developed by French and Morrison and was demonstrated to be effective. This is a formulation driven cognitive beh

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: At Risk Mental State (see page 7 and 8 of protocol) Age 18 to 35 years

Exclusion criteria

Exclusion criteria: current or previous receipt of antipsychotic medication moderate to severe learning disability; organic impairment non-Dutch speaking

Design outcomes

Primary

Measure	Time frame
Primary outcome: Rate of transitions to psychosis as defined in with the CAARMS criteria. The prescription of antipsychotic medication will be considered as a transition as well. At the transition to psychosis the PANSS and the PSYRATS will be administered and the SCID interview to diagnose the patient.	—

Secondary

Measure	Time frame
Secondary outcome measures and other products: 1) BDI (Beck Depression Inventory) 2) SIAS (Measure of social anxiety) 3) EQ5D (Health Questionnaire) 4) PBIQ-R (personal beliefs about illness) 5) MANSA (quality of life) 6) Medication check 7) Genetic material for genotyping at a later point in development. We expect higher transitions rates in people with the val/val genotype of the COMTval158met polimorsime, and the BDNFval166met met/met genotype. The first six measures are identical to the EDIE-2 study that now runs at Manchester, Birmingham, Glasgow, Cambridge and Norfolk. At the transition to psychosis the PANSS and the PSYRATS will be administered and the SCID interview to diagnose the patient. 8) Implementation of screening of all people in the age range from 18 to 35 that seek psychotherapeutic help at the mental health services in The Hague with the Prodromal Questionnaire. 9) Implementation of the CAARMS in the services in The Hague and Amsterdam to discriminate between normal, ARMS, and psychosis. 10) Implementation of a CBT intervention that is specifically adapted to treat ARMS with a co-morbid disorder. 11) Develop materials and training packages to facilitate spread of these kinds of services to other mental health facilities.	—

Measure

Time frame

Secondary outcome measures and other products: 1) BDI (Beck Depression Inventory) 2) SIAS (Measure of social anxiety) 3) EQ5D (Health Questionnaire) 4) PBIQ-R (personal beliefs about illness) 5) MANSA (quality of life) 6) Medication check 7) Genetic material for genotyping at a later point in development. We expect higher transitions rates in people with the val/val genotype of the COMTval158met polimorsime, and the BDNFval166met met/met genotype. The first six measures are identical to the EDIE-2 study that now runs at Manchester, Birmingham, Glasgow, Cambridge and Norfolk. At the transition to psychosis the PANSS and the PSYRATS will be administered and the SCID interview to diagnose the patient. 8) Implementation of screening of all people in the age range from 18 to 35 that seek psychotherapeutic help at the mental health services in The Hague with the Prodromal Questionnaire. 9) Implementation of the CAARMS in the services in The Hague and Amsterdam to discriminate between normal, ARMS, and psychosis. 10) Implementation of a CBT intervention that is specifically adapted to treat ARMS with a co-morbid disorder. 11) Develop materials and training packages to facilitate spread of these kinds of services to other mental health facilities.

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Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)