Quantitative monitoring of the inflammatory process in active HSV keratitis by in vivo confocal microscopy, a pilot study.

Quantitative monitoring of the inflammatory process in active HSV keratitis by in vivo confocal microscopy, a pilot study. - Monitoring of HSV keratitis by confocal microscopy.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON31356

Enrollment

Registered

2007-08-06

Start date

2008-02-08

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

herpetic keratitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age >=18 years. Informed consent. Unilateral active keratitis.

Exclusion criteria

Exclusion criteria: Corneal irregularity. Recently deteriorating cataract. Recently deteriorating retinal lesion.

Design outcomes

Primary

Measure	Time frame
- Confocal microscope: Stromal reflectivity (Z-scan, Area Under the Curve (AUC)) of HSV eye. - Clinical scoring form.	—

Secondary

Measure	Time frame
- Confocal microscope: Stromal reflectivity (Z-scan, AUC) fellow eye, Stromal reflectivity after 10 minutes HSV Eye (test reproducibility), Total corneal reflectivity, Reflectivity of anterior, median and posterior stroma separately. - Pachymetry: Tomey, Pentacam. - Slit lamp (maximal resolution): photograph central cornea, photograph paracentral cornea, blue light photograph (fluorescein drop), overall corneal photography. - Clinical scoring form based on slit lamp photography. - Vision: BCVA (ETDRS chart), Contrast sensitivity (Pelli-Robson chart), Intraocular stray light (Oculus C-quant).	—

Measure

Time frame

- Confocal microscope: Stromal reflectivity (Z-scan, AUC) fellow eye, Stromal reflectivity after 10 minutes HSV Eye (test reproducibility), Total corneal reflectivity, Reflectivity of anterior, median and posterior stroma separately. - Pachymetry: Tomey, Pentacam. - Slit lamp (maximal resolution): photograph central cornea, photograph paracentral cornea, blue light photograph (fluorescein drop), overall corneal photography. - Clinical scoring form based on slit lamp photography. - Vision: BCVA (ETDRS chart), Contrast sensitivity (Pelli-Robson chart), Intraocular stray light (Oculus C-quant).

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Countries

Netherlands

Outcome results