Local microvascular reactivity to Acetylcholine in patients with essential hypertension: possible interactions with the local renin-angiotensin system.

Local microvascular reactivity to Acetylcholine in patients with essential hypertension: possible interactions with the local renin-angiotensin system. - Local microvascular reactivity to Ach in hypertensive patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31352

Enrollment

Registered

2007-04-26

Start date

2007-06-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

high blood pressure Hypertension

Interventions

Local application of Acetylcholine, Sodium Nitroprusside, Angiotensin II and placebo in the bulbar conjunctiva (eye drops) and the finger skin (iontophoresis).

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria hypertensive patients: - Age:18-65 year - Caucasian - Untreated blood pressure > 140/90 mmHg - In consultation with the internist, anti-hypertensive medication will be stopped 3 weeks prior to the start of the experiment. ;Inclusion criteria normotensive volunteers: - Age:18-65 year - Caucasian - Blood pressure

Exclusion criteria

Exclusion criteria: - Secondary hypertension - Diabetes mellitus according to the criteria of the ADA - Kidney failure: serum creatinine > 150 µmol/l - Unable to stop blood pressure lowering medication during a period of 3 weeks - Use of blood cholesterol lowering medication - (Hypertensive) retinopathy, glaucoma or conjunctival disease - Connective tissue disease - Contact lenses

Design outcomes

Primary

Measure	Time frame
Changes in vascular diameters of bulbar conjunctiva, and changes in skin laser-Doppler flux.	—

Secondary

Measure	Time frame
/	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)