Effect of selective COX-2 inhibition on neuroinflammation in Parkinson's disease.

Effect of selective COX-2 inhibition on neuroinflammation in Parkinson's disease. - COX-2 inhibition in Parkinson's disease

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31350

Enrollment

Registered

2007-03-12

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paralysis agitans. Parkinson.

Interventions

Treatment Patients are informed about the possible side effects of the treatment by celecoxib as listed in the *Farmacotherapeutisch kompas 2005* and asked to contact the investigators if any effect

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age over 40 yr No cognitive disturbances Probable PD according to criteria by Gelb Early stage Hoehn and Yahr 1-2

Exclusion criteria

Exclusion criteria: Cardiovascular brain diseases Usage of antiinflammatory drugs Gastrointestinal ulcers or bleeding

Design outcomes

Primary

Measure	Time frame
Analysis methods [11C]-PK111-95 Binding Potential (BP) images will be generated based on a simplified reference tissue model4;13. Cluster analysis will be used to extract and identify a normal brain reference input function for individual PD cases. The reference tissue model will be compared to parametric analysis, using plasma input data and Logan analysis to generate distribution volume images. Pixel-by-pixel analysis will be done using Statistical Parametric Mapping program (SPM2)14. A coupled t-test will be applied to evaluate differences between the two scans. P-value of 0.001, uncorrected for multiple comparisons / 0.05 after correction will be taken for statistical significance.	—

Measure

Time frame

Analysis methods [11C]-PK111-95 Binding Potential (BP) images will be generated based on a simplified reference tissue model4;13. Cluster analysis will be used to extract and identify a normal brain reference input function for individual PD cases. The reference tissue model will be compared to parametric analysis, using plasma input data and Logan analysis to generate distribution volume images. Pixel-by-pixel analysis will be done using Statistical Parametric Mapping program (SPM2)14. A coupled t-test will be applied to evaluate differences between the two scans. P-value of 0.001, uncorrected for multiple comparisons / 0.05 after correction will be taken for statistical significance.

—

Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)