Hepatic insulin resistance and Dopaminergic dysfunction in a Ultra High Risk (UHR) population for Schizophrenia

Hepatic insulin resistance and Dopaminergic dysfunction in a Ultra High Risk (UHR) population for Schizophrenia - IHR-HIR

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON31345

Enrollment

Registered

2008-01-14

Start date

2007-09-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

delusion psychosis

Interventions

n.a.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age 18-35 "Ultra high risk" symptoms for development of psychosis as defined by McGorry et al (2002). Healthy controls matched for age, sex, BMI, IQ, ethnicity, viceral and subcutanious fat mass.

Exclusion criteria

Exclusion criteria: Previous psychotic episode Previous use of antipsychotics, or regular use of cocaine or amphetamins Type I and II diabetes mellitus Renal insufficiency Family history for type II diabetes mellitus. Familial dyslipidemia Treatment with drugs which are known to interfere with glucose or lipid metabolism Alcohol consumption in excess of 3 units per day or in the last 3 days before the clamp

Design outcomes

Primary

Measure	Time frame
Glucose productions (suppression)	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)