middelenafhankelijkheid (alcohol) alcohol dependence/alcohol addiction and pathological gambling/gambling addiction
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Problem drinkers need to meet 1 to 3 criteria of the DSM-IV criteria for alcohol abuse or alcohol dependence (assessed by CIDI section J). Clinical alcohol depended subjects need to score more than 3 criteria of the DSM-IV criteria for alcohol dependency (assessed by CIDI section J). Problem gamblers meet 3 from 5 DSM-IV criteria assessed by the DIS section T. Pathological gamblers meet 5 or more DSM-IV criteria assessed by the DIS section T. The control group does not have any history or presence of addictive behaviours.
Exclusion criteria
Exclusion criteria: Subjects are excluded when there is a history or presence of psychiatric disorders assessed by CIDI or DIS diagnostic interviews, such as: bipolar disorder, psychosis/hallucinations, manic, obsessive compulsive disorder or ADHD. Or if subjects have a history or presence of; neurological disorder (CVA, loss of consciousness>30 minutes, coma), hospitalization for psychiatric disorder(s), an estimated IQ lower than 85, or if they do not speak Dutch as their primary language. Subjects from the control groups are excluded when having a history of substance use or dependence, or pathological gambling (other than nicotine smoking). Men in the normal control group are excluded when drinking 21 or more alcoholic drinks a week; women are excluded when drinking more than 15 alcoholic drinks a week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Personality characteristics, behavioural scores, blood pressure, heart rate variability and brain activity (measured by functional MRI) are obtained. Genetic information will be derived by analysing blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| not applicable. | — |
Countries
Netherlands
Outcome results
None listed