high blood pressure Hypertension
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age >= 18 years - Patients with proven hypertension (i.e. blood pressure of > 140/90mmHg on repeated examination according to the criteria of the European Society of Hypertension).
Exclusion criteria
Exclusion criteria: - Routine MRI-contraindications (e.g. instable metal implants, pacemaker/ICD, vascular clips, atrial fibrillation or sustained ventricular tachycardia and claustrophobia). - Pregnancy - Renal insufficiency as defined by an MDRD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Manifestations of early end organ damage in patients with hypertension (i.e. the underneath mentioned MRI outcomes will be used to compare these between earlier mentioned hypertension subgroups): Heart: - Left Ventricular Function, Ejection Fraction, Volume and Mass - Delayed Contast Enhancement (DCE) to extent transmural left ventricular scar tissue Aorta: - Aortic wall compliance by distensibility and Pulse-wave velocity (PWV) Brain: - Precense and size of white matter lesions; - Presence and size of lacunar and cortical infarctions; - Brain atrophy and gray/white matter volumes; - Integrity of white matter fibers; - Prevalence of microbleeds. | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of early cardiac, cerebral and aortic target organ damage as assessed by 3 Tesla MRI, leading to more appropriate risk stratification for cardiovascular diseases in patients with hypertension. In our study we will assess early hypertensive induced target organ damage using Magnetic Resonance Imaging (MRI) technology with special emphasis on young patients and therapy resistant patients. Microalbuminuria and low grade systemic inflammation are expected to adversely affect the severity of target organ damage. | — |
Countries
Netherlands
Outcome results
None listed