diabetes impaired glucose tolerance
Conditions
Interventions
Each subject will be randomly assigned to one out of 24 treatment orders.
The four interventions are:
1) 0.5 L decaffeinated coffee (2 large cups)
2) ~1,000 mg chlorogenic acid (comparable to 1.0-2.0
Sponsors
Vrije Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Apparently healthy males as assessed by the questionnaires during the pre-study visit, and the results of the pre-study clinical laboratory tests and urinalysis - Age at screening: 18 years and above - Body mass index (BMI) between 25.0 and 35.0 kg/m2 - Regular coffee consumer (1 cup per day or more) - Willing to restrict coffee consumption during the study to max. 1 cup per day - Voluntary participation - Willing not to be blood or plasmaferese donor from 4 weeks before the start of the study until the end of study
Exclusion criteria
Exclusion criteria: - Women - Smokers - Subjects with diabetes will be excluded (fasting blood glucose >= 7.0 mmol/l or physician-diagnosis of diabetes) - Blood sampling is considered too difficult (assessed during pre-study screening) - Any chronic or acute disease (e.g. diabetes, renal disease, inflammation, cardiovascular disease). Therefore the medical questionnaire will be evaluated by a doctor from the research team. - Hypertension criteria for moderate hypertension WHO 2003: systolic > 140 mmHg or diastolic > 90 mmHg - Medical history or surgical events known to interfere with the study - Alcohol consumption > 28 consumptions per week - Self reported weight loss or gain > 2 kg in the month prior to screening - Any special diet (prescribed, slimming, macrobiotic or vegan). Sole exclusion of meat and fish from an otherwise *normal* western diet is allowed - Participation in any other trial up to 3 months before and during this study - Use of medication known to interfere with the study outcome e.g.: Medication interfering with digestion or glucose metabolism, such as corticosteroids and beta-blockers - Exercising more than 4 hours vigorously per regular week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentrations of glucose, insulin, glucagon-like peptide 1 secretion, and the activity of dipeptidyl peptidase IV will be measured during 2 hours following an oral glucose tolerance test. | — |
Secondary
| Measure | Time frame |
|---|---|
| N.A. | — |
Countries
Netherlands
Outcome results
None listed